Glucocorticoid Sensitivity in Mood Disorders
نویسندگان
چکیده
منابع مشابه
Neuroplasticity in mood disorders
Neuroimaging and neuropathological studies of major depressive disorder (MDD) and bipolar disorder (BD) have identified abnormalities of brain structure in areas of the prefrontal cortex, amygdala, striatum, hippocampus, parahippocampal gyrus, and raphe nucleus. These structural imaging abnormalities persist across illness episodes, and preliminary evidence suggests they may in some cases arise...
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The brain controls both the physiologic and the behavioral coping responses to daily events as well as major stressors, and the nervous system is itself a target of the mediators of those responses through circulating hormones. The amygdala and hippocampus interpret what is stressful and regulate appropriate responses. The amygdala becomes hyperactive in posttraumatic stress disorder (PTSD) and...
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OBJECTIVE Glucocorticoid (GC) sensitivity is highly variable among individuals and has been associated with susceptibility to develop (auto-)inflammatory disorders. The purpose of the study was to assess GC sensitivity in Behçet's disease (BD) by studying the distribution of four GC receptor (GR) gene polymorphisms and by measuring in vitro cellular GC sensitivity. METHODS Healthy controls an...
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There has been considerable interest in the neurocognitive functioning of subjects with mood disorders (Bcardcn ct al., 2001). I "'torn a theoretical viewpoint, the dysfunction provides insight (especially when monitored with fMlll) into the biological underpinnings, for example, structure and pathway integrity, of mood disorders. From a practical viewpoint, neurocognitive dysfunction underpins...
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ژورنال
عنوان ژورنال: Neuroendocrinology
سال: 2012
ISSN: 1423-0194,0028-3835
DOI: 10.1159/000329846